![]() The LC-MS/MS method was compared with frequently used enzymatic method and Jaffe method. After adding isotope-labeled Cre-d3 as internal standard, serum samples were prepared via a one-step protein precipitation with methanol. LC-MS/MS analysis was performed on API 4000 triple quadrupole mass spectrometer coupled with an Agilent 1200 liquid chromatography system. This study aims to develop a liquid chromatography tandem mass spectrometry (LC-MS/MS) method for serum Cre and compare this method with clinical routine methods. Differences among various methods of Cre quantification were previously noted. Accurate quantification of creatinine (Cre) is important to estimate glomerular filtration rate (GFR).
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